About Roma
Summary
ROMA is a prospective event-driven un-blinded randomized multicenter clinical trial. Patients will be randomized to a single arterial graft (SAG) or multiple arterial grafts (MAG). All patients will receive a single internal thoracic artery (ITA) to the left anterior descending coronary artery (LAD). In the Multiple Arterial Graft group, the major vessel to the lateral wall will be grafted with a radial or a second ITA. The primary outcome will be a composite of death from any cause, any stroke, post-discharge myocardial infarction and/or repeat revascularization. The secondary outcome will be all-cause mortality. The sample size is estimated at 4300 patients.
Investigators
Name |
Institution |
Location |
|---|---|---|
| Mario F. L. Gaudino MD, Principal Investigator | Department of Cardiothoracic Surgery, Weill Cornell Medicine | New York, NY, USA |
| Stephen Fremes MD, Principal Investigator | Sunnybrook Health Science, University of Toronto | Toronto, ON, Canada |
| John H. Alexander MD | Duke Clinical Research Institute, Duke Health | Durham, NC, USA |
| Faisal G. Bakaeen MD | Cleveland Clinic Foundation | Cleveland, OH, USA |
| Karla Ballman MD | Department of Biostatistics and Epidemiology, Weill Cornell Medicine | New York, NY, USA |
| Fabio Barili MD | Department of Cardiovascular Surgery, S. Croce e Carle Hospital | Cuneo, Italy |
| Antonio Maria Calafiore MD | Fondazione Giovanni Paolo II | Campobasso, Italy |
| Steven Goldman MD | Department of Medicine, University of Arizona | Tucson, AZ, USA |
| Peter Kappetein MD | Thoraxcenter, Erasmus MC | Rotterdam, Netherlands |
| Roberto Lorusso MD | Maastricht University Medical Centre | Maastricht, Netherlands |
| Darren Mylotte MD | Galway University Hospitals | Galway, Ireland |
| Domenico Pagano MD | University Hospital Birmingham | Birmingham, UK |
| Marc Ruel MD | University of Ottawa Heart Institute | Ottawa, ON, Canada |
| Thomas Schwann MD | The University of Toledo | Toledo, OH, USA |
| Hisayoshi Suma MD | Suma Heart Clinic | Tokyo, Japan |
| David P. Taggart MD | University of Oxford | Oxford, UK |
| Robert F. Tranbaugh MD | Department of Cardiothoracic Surgery, Weill Cornell Medicine | New York, NY, USA |